Unbiased Single‐Cell Sequencing of Hematopoietic and Immune Cells from Aplastic Anemia Reveals the Contributors of Hematopoiesis Failure and Dysfunctional Immune Regulation

Abstract Aplastic anemia (AA) is a bone marrow (BM) failure syndrome mediated by hyperactivated T‐cells with heterogeneous pathogenic factors. The onset of BM failure cannot be accurately determined in humans; therefore, exact pathogenesis remains unclear. In this study, a cellular atlas and microen...

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Autori principali:	Rongqun Guo, Jingjing Kong, Ping Tang, Shuya Wang, Lina Sang, Liu Liu, Rong Guo, Ketai Yan, Mochu Qi, Zhilei Bian, Yongping Song, Zhongxing Jiang, Yingmei Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2024-03-01
Serie:	Advanced Science
Soggetti:	aplastic anemia ferroptosis mass spectrometric analysis oxidized fatty acids metabolome scRNA‐seq
Accesso online:	https://doi.org/10.1002/advs.202304539
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