Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors

The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers–three components versions, and the van Leusen reaction, proved effective at provi...

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Hlavní autoři:	Emanuele Bassini, Stefano Gazzotti, Filomena Sannio, Leonardo Lo Presti, Jacopo Sgrignani, Jean-Denis Docquier, Giovanni Grazioso, Alessandra Silvani
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-05-01
Edice:	Antibiotics
Témata:	multicomponent reactions β-amino boronic acids β-lactamases covalent docking
On-line přístup:	https://www.mdpi.com/2079-6382/9/5/249
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