Spatial transcriptomics and neurofilament light chain reveal changes in lesion patterns in murine autoimmune neuroinflammation

Abstract Objective Ongoing neuroaxonal damage is a major contributor to disease progression and long-term disability in multiple sclerosis. However, spatio-temporal distribution and pathophysiological mechanisms of neuroaxonal damage during acute relapses and later chronic disease stages remain poor...

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Bibliografische gegevens

Hoofdauteurs:	Tobias Brummer, Miriam Schillner, Falk Steffen, Flores Kneilmann, Beatrice Wasser, Timo Uphaus, Frauke Zipp, Stefan Bittner
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2023-11-01
Reeks:	Journal of Neuroinflammation
Onderwerpen:	Multiple sclerosis Experimental autoimmune encephalomyelitis Serum neurofilament Microglia Spatial transcriptomics
Online toegang:	https://doi.org/10.1186/s12974-023-02947-y
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