The ISGylation tapestry in cancer: weaving phenotypic plasticity through multidimensional regulatory looms

Abstract Post-translational modification is an important mechanism for regulating protein function and cell signaling networks. Among these modifications, ISGylation is a ubiquitin-like modification regulated by ISG15. In this review, we explore the role of ISGylation in a variety of related phenoty...

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Autori principali:	Ruicheng Wu, Fanglin Shao, Siang Boon Koh, Uzoamaka Adaobi Okoli, Dengxiong Li, Jie Wang, Zhouting Tuo, Rong Zhang, Dilinaer Wusiman, Umber Cheema, Depei Kong, Dechao Feng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-11-01
Serie:	Cellular & Molecular Biology Letters
Soggetti:	Post-translational modification ISGylation Tumor microenvironment Immune evasion Drug resistance
Accesso online:	https://doi.org/10.1186/s11658-025-00815-6
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