Identification of dual STRN-NTRK2 rearrangements in a high grade sarcoma, with good clinical response to first-line larotrectinib therapy

Abstract Background Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors. More recently, the highly selective Trk tyrosine...

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Detalhes bibliográficos

Principais autores:	Ruihe Lin, Atrayee Basu Mallick, Zi-Xuan Wang, Scot Andrew Brown, Bo Lu, Wei Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-10-01
coleção:	Diagnostic Pathology
Assuntos:	STRN-NTRK2 fusion Sarcoma Next-generation sequencing Larotrectinib
Acesso em linha:	https://doi.org/10.1186/s13000-023-01400-1
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