Limitations of Semi-Automated Immunomagnetic Separation of HLA-G-Positive Trophoblasts from Papanicolaou Smears for Prenatal Genetic Diagnostics

<b>Background:</b> In prenatal genetic diagnostics, the detection of single-gene defects relies on chorionic villus sampling (CVS) and amniocentesis, which carry a miscarriage risk of 0.2–0.3%. To mitigate this risk, fetal trophoblasts have been isolated from a Papanicolaou smear using Trophoblast R...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Eddy N. de Boer, Nicole Corsten-Janssen, Elles Wierenga, Theo Bijma, Jurjen T. Knapper, Gerard J. te Meerman, Gwendolyn T. R. Manten, Nine V. A. M. Knoers, Katelijne Bouman, Leonie K. Duin, Cleo C. van Diemen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2025-02-01
Schriftenreihe:	Diagnostics
Schlagworte:	prenatal genetic diagnostics single-gene defects fetal trophoblasts Papanicolaou smear semi-automated immunomagnetic cell sorting
Online-Zugang:	https://www.mdpi.com/2075-4418/15/3/386
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!