HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape

Abstract Background Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dynamics. Despite HDAC6’s potential therapeutic value,...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Michela Gottardi Zamperla, Barbara Illi, Veronica Barbi, Chiara Cencioni, Daniele Santoni, Stella Gagliardi, Maria Garofalo, Gabriele Antonio Zingale, Irene Pandino, Diego Sbardella, Lina Cipolla, Simone Sabbioneda, Antonella Farsetti, Chiara Ripamonti, Gianluca Fossati, Christian Steinkühler, Carlo Gaetano, Sandra Atlante
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2024-08-01
Σειρά:	Clinical Epigenetics
Θέματα:	HDAC HAT Deacetylase inhibitors Cancer Tumorigenesis Histone acetylation
Διαθέσιμο Online:	https://doi.org/10.1186/s13148-024-01725-8
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