Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin

Acute β-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical curcumin. Differentiated H9C...

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Bibliographic Details

Main Authors:	Jin Hee Lee, Da Hae Kim, MinA Kim, Kyung-Ho Jung, Kyung-Han Lee
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2022-02-01
Series:	Molecules
Subjects:	isoproterenol-induced cardiotoxicity cardiomyocyte reactive oxygen species p53 curcumin
Online Access:	https://www.mdpi.com/1420-3049/27/4/1346
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