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Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts

Background Hematopoietic stem cells are retained within discrete bone marrow niches through the effects of cell adhesion molecules and chemokine gradients. However, a small proportion of hematopoietic stem cells can also be found trafficking in the peripheral blood. During induced stem cell mobiliza...

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Autori principali: Nicole D. Staudt, Wilhelm K. Aicher, Hubert Kalbacher, Stefan Stevanovic, Adriana K. Carmona, Matthew Bogyo, Gerd Klein
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2010-09-01
Serie:Haematologica
Accesso online:https://haematologica.org/article/view/5707
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