STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death

<p>Abstract</p> <p>Background</p> <p>In an effort to achieve better cancer therapies, we elucidated the combination cancer therapy of STI571 (an inhibitor of Bcr-Abl and clinically used for chronic myelogenous leukemia) and TNF-related apoptosis-inducing ligand (TRAIL, a developing antitumor agent)...

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Detalhes bibliográficos

Principais autores:	Huang Duen-Yi, Chao Yee, Tai Ming-Hui, Yu Yang-Hao, Lin Wan-Wan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2012-03-01
coleção:	Journal of Biomedical Science
Assuntos:	STI571 TRAIL Antitumor Stress kinases Apoptosis
Acesso em linha:	http://www.jbiomedsci.com/content/19/1/35
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