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Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease

Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) activation occurs in the liver in response to the nutritional and metabolic stress. The aberrant activation of MAPKs, especi...

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Principais autores: Robert W. M. Min, Filbert W. M. Aung, Bryant Liu, Aliza Arya, Sanda Win
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-08-01
Serier:Biomedicines
Fag:
JNK
SAB
JNK activation loop
ROS
MAP kinase cascade
drug therapy
Online adgang:https://www.mdpi.com/2227-9059/10/8/2035
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