Allostery in homodimeric SARS-CoV-2 main protease
Abstract Many enzymes work as homodimers with two distant catalytic sites, but the reason for this choice is often not clear. For the main protease Mpro of SARS-CoV-2, dimerization is essential for function and plays a regulatory role during the coronaviral replication process. Here, to analyze a po...
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| Principais autores: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Portfolio
2024-11-01
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| Serier: | Communications Biology |
| Online adgang: | https://doi.org/10.1038/s42003-024-07138-w |
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