Role of antibiotic use, plasma citrulline and blood microbiome in advanced non-small cell lung cancer patients treated with nivolumab

Abstract Background Recent data suggested a role of gut microbiota and antibiotic use on immune checkpoint inhibitors efficacy. We aimed to evaluate the impact of early use of antibiotic (EUA), blood microbiome and plasmatic citrulline (marker of the intestinal barrier) on nivolumab efficacy in non-...

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Autori principali:	Julia Ouaknine Krief, Pierre Helly de Tauriers, Coraline Dumenil, Nathalie Neveux, Jennifer Dumoulin, Violaine Giraud, Sylvie Labrune, Julie Tisserand, Catherine Julie, Jean-François Emile, Thierry Chinet, Etienne Giroux Leprieur
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMJ Publishing Group 2019-07-01
Serie:	Journal for ImmunoTherapy of Cancer
Soggetti:	Non-small cell lung cancer Antibiotic Plasma Blood Microbiome Citrulline
Accesso online:	http://link.springer.com/article/10.1186/s40425-019-0658-1
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