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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

Summary: Type I interferon (IFN-I) and IFN-γ foster antitumor immunity by facilitating T cell responses. Paradoxically, IFNs may promote T cell exhaustion by activating immune checkpoints. The downstream regulators of these disparate responses are incompletely understood. Here, we describe how inter...

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Principais autores: Prabhat K. Purbey, Joowon Seo, Manash K. Paul, Keisuke S. Iwamoto, Allison E. Daly, An-Chieh Feng, Ameya S. Champhekar, Justin Langerman, Katie M. Campbell, Dörthe Schaue, William H. McBride, Steven M. Dubinett, Antoni Ribas, Stephen T. Smale, Philip O. Scumpia
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-06-01
Serier:Cell Reports
Fag:
CP: Immunology
CP: Cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S221112472400617X
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