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The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation

Therapeutics that block tumor necrosis factor (TNF), and thus activation of TNF receptor 1 (TNFR1) and TNFR2, are clinically used to treat inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and psoriasis. However, TNFR1 and TNFR2 work antithetically to balance immune resp...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Fabian Richter, Sarah K. Williams, Katharina John, Carina Huber, Camille Vaslin, Henri Zanker, Richard Fairless, Kira Pichi, Silke Marhenke, Arndt Vogel, Marie-Ann Dhaen, Stefanie Herrmann, Andreas Herrmann, Klaus Pfizenmaier, Heike Bantel, Ricarda Diem, Roland E. Kontermann, Roman Fischer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021-07-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
TNF
TNFR1
inflammatory diseases
arthritis
EAE
multiple sclerosis
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.705485/full
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