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CYP2B6 polymorphisms and suicidal behaviour in people living with HIV treated with efavirenz-containing combination antiretroviral therapy: a global case–control study

BackgroundWe analysed the association between host genetic risk scores (GRSs) predicting efavirenz (EFV) plasma levels and exposure and suicidal behaviours in participants in one of several global antiretroviral therapy (ART) clinical trials linked to the International Network for Strategic Initiati...

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Huvudupphov: Alejandro Arenas-Pinto, Jacqueline Nordwall, Dianne Carey, Courtney V. Fletcher, Andrew D. Badley, Greg Thompson, Cavan Reilly, Sandra E. Safo, Birgit Grund, Jens Lundgren
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2026-04-01
Serie:Frontiers in Pharmacology
Ämnen:
CYP2B6
efavirenz
HIV
pharmacogenomics
suicidal behaviour
suicidality
Länkar:https://www.frontiersin.org/articles/10.3389/fphar.2026.1734919/full
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