Gene expression profiling in frataxin deficient mice: Microarray evidence for significant expression changes without detectable neurodegeneration

Friedreich's ataxia (FRDA) is caused by reduction of frataxin levels to 5–35%. To better understand the biochemical sequelae of frataxin reduction, in absence of the confounding effects of neurodegeneration, we studied the gene expression profile of a mouse model expressing 25–36% of the normal frat...

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Detalhes bibliográficos

Principais autores:	Giovanni Coppola, Sang-Hyun Choi, Manuela M. Santos, Carlos J. Miranda, Dmitri Tentler, Eric M. Wexler, Massimo Pandolfo, Daniel H. Geschwind
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2006-05-01
coleção:	Neurobiology of Disease
Assuntos:	Friedreich's ataxia Microarray Mouse model Frataxin Neurodegeneration Knockin/knockout
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S096999610500313X
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