Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease

The macrophage migration inhibitory factor (MIF) expressed in hepatocytes can limit steatosis during obesity. Lipotoxicity in nonalcoholic fatty liver disease is mediated in part by the activation of the stress kinase JNK, but whether MIF modulates JNK in lipotoxicity is unknown. In this study, we i...

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Hlavní autoři:	Ni Cui, Hui Li, Yaoshan Dun, Jeffrey W. Ripley-Gonzalez, Baiyang You, Dezhao Li, Yuan Liu, Ling Qiu, Cui Li, Suixin Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-09-01
Edice:	Frontiers in Endocrinology
Témata:	exercise NAFLD (non alcoholic fatty liver disease) MIF — macrophage migration inhibitory factor lipotocixity JNK
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2022.961231/full
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