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An Approach to Evaluate the Effective Cytoplasmic Concentration of Bioactive Agents Interacting with a Selected Intracellular Target Protein

To compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents. In this work, based on a simple equilibrium model and the cellular therm...

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Principais autores: Yuri V. Khramtsov, Alexey V. Ulasov, Andrey A. Rosenkranz, Tatiana A. Slastnikova, Tatiana N. Lupanova, Georgii P. Georgiev, Alexander S. Sobolev
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-01-01
coleção:Pharmaceutics
Assuntos:
intracellular concentrations
Nrf2
Keap1
equilibrium model
CETSA
exogenous competitors
Acesso em linha:https://www.mdpi.com/1999-4923/15/2/324
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