Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

While studying transgenic mice that overexpress human wildtype alpha-synuclein (Thy1-ASO, ASO) for typical brain alpha-synucleinopathy and central nervous system neuropathology, we observed progressive functional changes in the gastrointestinal and other peripheral organs. A more systematic study re...

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Bibliografische Detailangaben

Hauptverfasser:	Penelope J. Hallett, Jesse R. McLean, Andrew Kartunen, J. William Langston, Ole Isacson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2012-08-01
Schriftenreihe:	Neurobiology of Disease
Schlagworte:	Alpha-synuclein Synucleinopathy Parkinson's disease Constipation Gastrointestinal Autonomic
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0969996112001386
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