Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

Rabbits produce robust antibody responses and have unique features in their antibody repertoire that make them an attractive alternative to rodents for in vivo discovery. However, the frequent occurrence of a non-canonical disulfide bond between complementarity-determining region (CDR) H1 (C35a) and...

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מידע ביבליוגרפי

Principais autores:	Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis Group 2024-12-01
סדרה:	mAbs
נושאים:	Complementarity determining regions (CDRs) disulfide bond humanization ML/AI-guided protein design Programmed cell death (PD-1) Rabbit monoclonal antibody (mab)
גישה מקוונת:	https://www.tandfonline.com/doi/10.1080/19420862.2024.2309685
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