Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathy featured by life‐threatening arrhythmias. While TMEM43 has been identified as an ARVC‐associated gene, molecular links between TMEM43 mutations and electrophysiological abnormalities in ARVC remain lar...

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Bibliografiske detaljer

Principais autores:	Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wiley 2025-12-01
Serier:	Advanced Science
Fag:	arrhythmia ARVC iPSC‐CMs lamin B2 RYR2 TMEM43
Online adgang:	https://doi.org/10.1002/advs.202512058
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