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Astragaloside IV attenuates sunitinib-associated cardiotoxicity by inhibiting COUP-TFII

Sunitinib (SU) is widely used to treat solid tumors but it can be cardiotoxic and often leads to drug withdrawn or discontinuation. Astragaloside IV (ASIV) is the essential active component of the Chinese herb Astragalus membranaceus which shows potential cardioprotective effects. Herein, we investi...

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Principais autores: Wanting Qin, Shaoling Li, Ziji Cheng, Wenlong Xue, Mingyue Tian, Fangfang Mou, Haidong Guo, Shuijin Shao, Baonian Liu
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2024-02-01
Series:Heliyon
Assuntos:
Astragaloside IV
Sunitinib-associated cardiotoxicity
COUP-TFII
Oxidative stress
Apoptosis
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405844024008107
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