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Esketamine relieves depressive-like behaviors in MPTP-induced Parkinson disease mice via GPR109A-dependent reduction of neuroinflammation

Background: Depression is a common complication of Parkinson disease (PD). This study investigated whether a single dose of esketamine could alleviate depressive symptoms in an MPTP mouse model by activating G protein-coupled receptor 109 A (GPR109A) and reducing neuroinflammation. Methods: Adult ma...

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I tiakina i:
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Ngā kaituhi matua: Shu Wang, Wei Song, Yuanyuan Gao, Wei Tan, Lin Ji, Chen Wang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2025-11-01
Rangatū:Brain Research Bulletin
Ngā marau:
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S0361923025004071
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