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Targeting arginine metabolism overcomes chemotherapy resistance in aggressive-variant prostate cancers

Summary: Aggressive-variant prostate cancers (AVPCs) respond poorly to anti-androgen therapy but show sensitivity to taxane-platinum chemotherapy, though outcomes remain poor. We conducted a phase 2 trial testing induction cabazitaxel plus carboplatin (CabCarb) followed by olaparib maintenance versu...

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Hoofdauteurs: Elavarasan Subramani, Patrick G. Pilié, Rebecca Slack-Tidwell, Paul V. Viscuse, Xianghong Kuang, Thirukumaran Kandasamy, Dominik Awad, Jenny J. Han, Licai Huang, Christine B. Peterson, Amado J. Zurita, Sumit K. Subudhi, Paul G. Corn, Rama Soundararajan, Peter Shepherd, Badrajee Piyarathna, Vasanta Putluri, Nagireddy Putluri, Arun Sreekumar, Yuzhuo Wang, Amina Zoubeidi, Iqbal Mahmud, Sara A. Martinez, Lin Tan, Philip L. Lorenzi, Sreyashi Basu, Sonali Jindal, Padmanee Sharma, Christopher J. Logothetis, Timothy C. Thompson, Daniel E. Frigo, Ana M. Aparicio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2026-06-01
Reeks:iScience
Onderwerpen:
Health sciences
Medicine
Medical specialty
Oncology
Online toegang:http://www.sciencedirect.com/science/article/pii/S2589004226015592
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