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Integrated spatial and single‑cell transcriptomics maps disulfidptosis in renal cell carcinoma and reveals PDLIM1 as a prognostic biomarker and potential therapeutic target

Background: Disulfidptosis is a regulated cell death program linked to redox stress, metabolism, and the actin cytoskeleton. Its organization in tissue and clinical relevance in renal cell carcinoma are not well defined. Methods: We integrated spatial transcriptomics from six renal cancer sections w...

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Principais autores: Wenqiang Liu, Xianglin Liu, Juan Yi, Zhao Tang, Ziwen Dai, Jiaao Song, Tong Chen, Jun Wang, Jiaxuan Wang, Wentao Jiang, Aimin Jiang, Zhenjie Wu, Lifang Tang, Yuming Jin, Yinghu Chen, Linhui Wang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-06-01
Serier:Translational Oncology
Fag:
Renal cell carcinoma
Spatial transcriptomics
scRNA-seq
Disulfidptosis
Online adgang:http://www.sciencedirect.com/science/article/pii/S1936523326001026
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