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Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

Abstract A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes and adipose tissue dysfunction remains incompletely un...

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Hlavní autoři: Klara Piletic, Amir H. Kayvanjoo, Felix Clemens Richter, Mariana Borsa, Ana V. Lechuga-Vieco, Oliver Popp, Sacha Grenet, Jacky Ka Long Ko, Lin Luo, Kristina Zec, Maria Kyriazi, Harriet K. Haysom, Lada Koneva, Stephen Sansom, Philipp Mertins, Fiona Powrie, Ghada Alsaleh, Anna Katharina Simon
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-10-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-025-64266-5
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