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Aiolos and Eos drive distinct human TH17 functional states

Abstract CD4+ T helper (TH)-17 cells play a pivotal role in mucosal immune defense and are implicated in autoimmune diseases and cancer. Although Th17 cell plasticity is well-studied in mice, the factors driving their transition between pro-inflammatory and immunomodulatory states in humans remain l...

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Principais autores: Silvia Cerboni, Leila Mohammadnezhad, Komal Agrawal, Ramachandramouli Budida, Ilenia Papa, Silvia Gaggero, Joel Dulong, Anna Cole, Anja Mezger, Bingyu Yan, Zonghao Zhang, Elisabeth Israelsson, Petr Volkov, Songyuan Li, Eva F. Caceres, Malo Leprohon, Mojtaba Shekarkar Azgomi, Yue Cui, Svitlana Salemio, Mike Firth, Leif Wigge, Anna Rudin, Hanna Grindebacke, Marcello Maresca, Chrystal Paulos, Franck Morschhauser, Salomon Manier, Majid Kazemian, Arian Laurence, Michael Hühn, Ulf Gehrmann, Karin Tarte, Suman Mitra
Format: Artigo
Jezik:Inglês
Izdano: Springer 2026-04-01
Serija:Cellular and Molecular Life Sciences
Teme:
TH17 cells
IkZF transcription factors
Lenalidomide
IL-10
IL-22
T cell plasticity
Online dostop:https://doi.org/10.1007/s00018-026-06089-1
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