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Design, Synthesis, and Evaluation of Homochiral Peptides Containing Arginine and Histidine as Molecular Transporters

Linear (HR)n and cyclic [HR]n peptides (n = 4,5) containing alternate arginine and histidine residues were synthesized. The peptides showed 0–15% cytotoxicity at 5–100 µM in human ovarian adenocarcinoma (SK-OV-3) cells while they exhibited 0–12% toxicity in human leukemia can...

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Principais autores: Naglaa Salem El-Sayed, Taryn Miyake, Amir N. Shirazi, Shang Eun Park, Jimmy Clark, Stephani Buchholz, Keykavous Parang, Rakesh Tiwari
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-06-01
Serier:Molecules
Fag:
anticancer drugs
fatty acyl peptides
histidine
phosphopeptides
molecular transporters
cytotoxicity
Online adgang:http://www.mdpi.com/1420-3049/23/7/1590
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