mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling pathway is involved in cellular senescence, organismal aging and age-dependent diseases. mTOR is a conserved serine/threonine kinase that is known to be part of two different protein complexes: mTORC1 and mTORC2, w...

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Hlavní autoři:	Marzia Perluigi, Fabio Di Domenico, D. Allan Butterfield
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2015-12-01
Edice:	Neurobiology of Disease
Témata:	mTOR Alzheimer disease Autophagy Down Syndrome
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996115000868
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