Probiotic as Adjuvant Significantly Improves Protection of the Lanzhou Trivalent Rotavirus Vaccine against Heterologous Challenge in a Gnotobiotic Pig Model of Human Rotavirus Infection and Disease

This preclinical study in the gnotobiotic (Gn) pig model of human rotavirus (HRV) infection and disease evaluates the effect of probiotic <i>Lactobacillus rhamnosus</i> GG (LGG) as a mucosal adjuvant on the immunogenicity and cross-protective efficacy of the Lanzhou live oral trivalent (G2, G3, G4)...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Viviana Parreno, Muqun Bai, Fangning Liu, Jiqiang Jing, Erika Olney, Guohua Li, Ke Wen, Xingdong Yang, Tammy Bui Castellucc, Jacob F. Kocher, Xu Zhou, Lijuan Yuan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-09-01
Schriftenreihe:	Vaccines
Schlagworte:	rotavirus vaccine probiotic adjuvant <i>Lactobacillus rhamnosus</i> GG Lanzhou trivalent vaccine gnotobiotic pig
Online-Zugang:	https://www.mdpi.com/2076-393X/10/9/1529
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