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Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential

A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2–5 steps and their structure was proved by elemental and spectral analyses. The compounds obtained were evaluated in vitro against the promastigote stage of the kinetoplastid parasite <i>Leishmania infant...

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Principais autores: Omar Khoumeri, Sébastien Hutter, Nicolas Primas, Caroline Castera-Ducros, Sandra Carvalho, Susan Wyllie, Mohamed Lotfi Efrit, Dimitri Fayolle, Marc Since, Patrice Vanelle, Pierre Verhaeghe, Nadine Azas, Hussein El-Kashef
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-07-01
Serier:Pharmaceuticals
Fag:
visceral leishmaniasis
<i>L. infantum</i>
thiazolidinedione ring
nitrostyryl moiety
Online adgang:https://www.mdpi.com/1424-8247/17/7/878
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