Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation
Summary: DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome bridges and ultra-fine DNA bridges (UFBs) arise in anaphase. The TopoIIα C-terminal domain is dispensable for the SPR in vitro...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Elsevier
2023-05-01
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| Seri Bilgileri: | iScience |
| Konular: | |
| Online Erişim: | http://www.sciencedirect.com/science/article/pii/S2589004223008209 |
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