Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial

Summary: Background: COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and immunogenicity in healthy adults. Methods: This combined open-label and randomised, phase 1 trial was done at the City of Ho...

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Principais autores:	Flavia Chiuppesi, PhD, John A Zaia, ProfMD, Paul H Frankel, ProfPhD, Rodica Stan, PhD, Jennifer Drake, RN, Brenda Williams, RN, Anne Marie Acosta, LVN, Karyn Francis, RN, Randy A Taplitz, ProfMD, Janet K Dickter, MD, Sanjeet Dadwal, MD, Alfredo G Puing, MD, Deepa D Nanayakkara, MD, Patricia Ash, RN, Yujie Cui, MS, Heidi Contreras, PhD, Corinna La Rosa, PhD, Katrin Tiemann, PhD, Yoonsuh Park, PhD, Joybelle Medina, MS, Angelina Iniguez, MS, Qiao Zhou, MS, Veronica Karpinski, MS, Daisy Johnson, MS, Katelyn Faircloth, MS, Teadora Kaltcheva, PhD, Jenny Nguyen, MS, Mindy Kha, MS, Vu H Nguyen, PhD, Sandra Ortega Francisco, PhD, Alba Grifoni, PhD, Angela Wong, MS, Alessandro Sette, PhD, Felix Wussow, PhD, Don J Diamond, ProfPhD
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-04-01
coleção:	The Lancet Microbe
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2666524722000271
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