Development of an icIEF assay for monitoring AAV capsid proteins and application to gene therapy products

Adeno-associated virus (AAV) gene therapy vectors, which contain a DNA transgene packaged into a protein capsid, have shown tremendous therapeutic potential in recent years. Methods traditionally used in quality control labs, such as high-performance liquid chromatography (HPLC) and capillary electr...

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Detalhes bibliográficos

Principais autores:	Xiaoping Z. He, Thomas W. Powers, Sisi Huang, Zhenjiu Liu, Heliang Shi, John D. Orlet, Jim J. Mo, Saipraveen Srinivasan, Steven Jacobs, Kun Zhang, Herbert A. Runnels, Melissa M. Anderson, Thomas F. Lerch
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-06-01
coleção:	Molecular Therapy: Methods & Clinical Development
Assuntos:	gene therapy research icIEF charge heterogeneity determination AAV deamidation LC-MS
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2329050123000384
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