Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling

Abstract Background Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity. Its expression level is increased in activated immune cells including dendritic cells, macrophages, and microglia. We have previously reported that CatH deficiency impairs toll-like recepto...

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Detalhes bibliográficos

Principais autores:	Junjun Ni, Juan Zhao, Xinwen Zhang, Thomas Reinheckel, Vito Turk, Hiroshi Nakanishi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-08-01
coleção:	Journal of Neuroinflammation
Assuntos:	Cathepsin H Interferon-β Microglia/Macrophages Astrocyte
Acesso em linha:	https://doi.org/10.1186/s12974-021-02227-7
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