Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors.

Antibody-dependent cellular cytotoxicity (ADCC) is an important effector function determining the clinical efficacy of therapeutic antibodies. Core fucose removal from N-glycans on the Fc portion of immunoglobulin G (IgG) improves the binding affinity for Fcγ receptor IIIa (FcγRIIIa) and dramaticall...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yuya Isoda, Hirokazu Yagi, Tadashi Satoh, Mami Shibata-Koyama, Kazuhiro Masuda, Mitsuo Satoh, Koichi Kato, Shigeru Iida
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2015-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4596520?pdf=render
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!