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Clinical Molecular Immunohistochemistry Mismatch Repair Mutations in Lynch Syndrome in Patients Under 50 Years: A Systematic Review

<b>Background and Objectives</b>: Lynch syndrome (LS), an autosomal dominant condition arising from germline mutations in mismatch repair (MMR) genes, is a major cause of hereditary early-onset colorectal cancer (CRC). Although patients diagnosed before age 50 represent a critical subgroup where Lyn...

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Glavni autori: Bogdan Adrian Manta, Adrian Cosmin Ilie, Felicia Marc, Daciana Nistor, Patricia Octavia Mazilu, Claudia Borza
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2025-04-01
Serija:Biomedicines
Teme:
Lynch syndrome
mismatch repair deficiency
immunohistochemistry
early-onset colorectal cancer
molecular testing
Online pristup:https://www.mdpi.com/2227-9059/13/5/1062
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