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In Silico and In Vitro Studies on an Asymmetrical Porphyrin Derivative with Therapeutic Potential in Skin Disorders

For developing novel photosensitizers with therapeutic potential in non-malignant and malignant cutaneous disorders, the unsymmetrical porphyrin, 5-(2-hydroxy-3-methoxyphenyl)-10, 15, 20-<i>tris</i>-(4-carboxymethylphenyl) porphyrin, was evaluated <i>in silico</i> and <i>in vitro.</i> The cellular u...

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Principais autores: Andreea Mihaela Burloiu, Dragos Paul Mihai, Gina Manda, Dumitru Lupuliasa, Ionela Victoria Neagoe, Radu Petre Socoteanu, Mihaela Surcel, Laurentiu-Iliuta Anghelache, Laura Olariu, Cerasela Elena Gîrd, Rica Boscencu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-05-01
Serier:Pharmaceuticals
Fag:
asymmetrical porphyrin
photodynamic therapy
HaCaT keratinocytes
Hs27 skin fibroblasts
carbonic anhydrase IX
molecular dynamics
Online adgang:https://www.mdpi.com/1424-8247/17/6/688
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