TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer

In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is required to amplify ATR kinase activity to the levels needed to coordinate the D...

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Autors principals:	Laura Morano, Nadia Vezzio-Vié, Adam Aissanou, Tom Egger, Antoine Aze, Solène Fiachetti, Benoit Bordignon, Cedric Hassen-khodja, Hervé Seitz, Louis-Antoine Milazzo, Véronique Garambois, Laurent Chaloin, Nathalie Bonnefoy, Céline Gongora, Angelos Constantinou, Jihane Basbous
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2025-10-01
Col·lecció:	eLife
Matèries:	biomolecul condensate targeted therapy TopBP1/ATR pathway replication stress response
Accés en línia:	https://elifesciences.org/articles/106196
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