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CX3CR1 upregulation modulates microglial activation and preserves synapses in the hippocampus and frontal cortex of middle-aged mice

IntroductionThe aging brain shows alterations in microglial function, morphology, and phenotype, reflecting a state of chronic activation. CX3CR1 plays a critical role in regulating microglial chemotaxis, phagocytosis, and activation. However, its exact role in the aging brain is not well understood...

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Principais autores: Jinfeng Liu, Zhongqing Sun, Xin Liu, Kin Chiu, Lan Ma, Jiantao Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-07-01
Serier:Frontiers in Aging
Fag:
CX3CR1
microglia
aging brain
synaptic homeostasis
hippocampus
frontal cortex
Online adgang:https://www.frontiersin.org/articles/10.3389/fragi.2025.1549848/full
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