Relationship between Oxidative Stress and Imatinib Resistance in Model Chronic Myeloid Leukemia Cells

Chronic myeloid leukemia (CML) develops due to the presence of the BCR-ABL1 protein, a target of tyrosine kinase inhibitors (TKIs), such as imatinib (IM), used in a CML therapy. CML eradication is a challenge due to developing resistance to TKIs. BCR-ABL1 induces endogenous oxidative stress leading...

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主要な著者:	Sylwester Głowacki, Ewelina Synowiec, Marzena Szwed, Monika Toma, Tomasz Skorski, Tomasz Śliwiński
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2021-04-01
シリーズ:	Biomolecules
主題:	chronic myeloid leukemia imatinib reactive oxygen species
オンライン･アクセス:	https://www.mdpi.com/2218-273X/11/4/610
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