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Gene and metabolite expression dependence on body mass index in human myocardium

Abstract We hypothesized that body mass index (BMI) dependent changes in myocardial gene expression and energy-related metabolites underlie the biphasic association between BMI and mortality (the obesity paradox) in cardiac surgery. We performed transcriptome profiling and measured a panel of 144 me...

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Principais autores: Adewale S. Adebayo, Marius Roman, Mustafa Zakkar, Syabira Yusoff, Melanie Gulston, Lathishia Joel-David, Bony Anthony, Florence Y. Lai, Antonio Murgia, Bryony Eagle-Hemming, Sophia Sheikh, Tracy Kumar, Hardeep Aujla, Will Dott, Julian L. Griffin, Gavin J. Murphy, Marcin J. Woźniak
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2022-01-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-022-05562-8
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