Chemical genetics reveals an RGS/G-protein role in the action of a compound.

We report here on a chemical genetic screen designed to address the mechanism of action of a small molecule. Small molecules that were active in models of urinary incontinence were tested on the nematode Caenorhabditis elegans, and the resulting phenotypes were used as readouts in a genetic screen t...

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Bibliografiske detaljer

Principais autores:	Kevin Fitzgerald, Svetlana Tertyshnikova, Lisa Moore, Lynn Bjerke, Ben Burley, Jian Cao, Pamela Carroll, Robert Choy, Steve Doberstein, Yves Dubaquie, Yvonne Franke, Jenny Kopczynski, Hendrik Korswagen, Stanley R Krystek, Nicholas J Lodge, Ronald Plasterk, John Starrett, Terry Stouch, George Thalody, Honey Wayne, Alexander van der Linden, Yongmei Zhang, Stephen G Walker, Mark Cockett, Judi Wardwell-Swanson, Petra Ross-Macdonald, Rachel M Kindt
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2006-04-01
Serier:	PLoS Genetics
Online adgang:	http://europepmc.org/articles/PMC1440875?pdf=render
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