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Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.

Many cell lines derived from tumors as well as transformed cell lines are far more sensitive to V-ATPase inhibitors than normal counterparts. The molecular mechanisms underlying these differences in sensitivity are not known. Using global gene expression data, we show that the most sensitive respons...

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Principais autores: Sarah Straud, Iryna Zubovych, Jef K De Brabander, Michael G Roth
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-07-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2905441?pdf=render
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