From Glycocalyx Shedding to Microvascular Collapse in Sepsis: Endothelial Pathophysiology, Organ Dysfunction, and Mechanistic Biomarkers

Sepsis is a systemic disorder in which infection-induced inflammation progressively disrupts vascular homeostasis and drives organ dysfunction. This review reframes septic pathophysiology as a sequential and self-amplifying process centered on endothelial failure. Early activation of innate immune p...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jhan S. Saavedra-Torres, Lady Viviana Acosta Castillo, Alexandra Montoya Rendon, Daniel Esteban Castro Valencia, Diego A. Lucero Guanga, Manuela Garzon Ovalle, Fabián Darío Arias Rodríguez, Andrés López-Cortés, Juan S. Izquierdo-Condoy
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2026-05-01
Schriftenreihe:	Pathophysiology
Schlagworte:	sepsis endothelial dysfunction glycocalyx syndecan-1 microvascular coagulopathy
Online-Zugang:	https://www.mdpi.com/1873-149X/33/2/36
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