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Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors

A library of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates was synthesised by selective S-alkylation of the easily accessible 4-thioureidobenzenesulphonamide. The compounds were assayed as inhibitors of four human (h) carbonic anhydrase isoforms hCA I, II, VII, and XIII, as well as thre...

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Principais autores: Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran, Raivis Žalubovskis
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2023-12-01
Serier:Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:
Carbonic anhydrase
inhibitors
sulphonamides
carbamimidothioates
bacterial enzymes
Online adgang:https://www.tandfonline.com/doi/10.1080/14756366.2022.2152811
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