Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain

Familial dysbetalipoproteinemia associated with the apolipoprotein E2 (APOE2) genotype is a recessive disorder with low penetrance. We have investigated whether additional expression of full-length APOE3, APOE4, or a truncated variant of APOE4 (APOE4-202) can reduce APOE2- associated hyperlipidemia....

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Auteurs principaux:	Gery Gerritsen, Kyriakos E. Kypreos, André van der Zee, Bas Teusink, Vassilis I. Zannis, Louis M. Havekes, Ko Willems van Dijk
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2003-02-01
Collection:	Journal of Lipid Research
Sujets:	familial dysbetalipoproteinemia adenovirus-mediated gene transfer hypertriglyceridemia apolipoprotein E
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S0022227520312281
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