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Biodistribution and Biosafety of a Poly(Phosphorhydrazone) Dendrimer, an Anti-Inflammatory Drug-Candidate

Dendrimers are nanosized, arborescent polymers of which size and structure are perfectly controlled. This is one reason why they are widely used for biomedical purposes. Previously, we showed that a phosphorus-based dendrimer capped with anionic azabisphosphonate groups (so-called ABP dendrimer) has...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Séverine Fruchon, Elisabeth Bellard, Nicolas Beton, Cécile Goursat, Abdelouahd Oukhrib, Anne-Marie Caminade, Muriel Blanzat, Cédric-Olivier Turrin, Muriel Golzio, Rémy Poupot
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2019-09-01
Schriftenreihe:Biomolecules
Schlagworte:
azabisphosphonate
biodistribution
dendrimers
drug candidate
preclinical development
rabbit
rodents
safety
Online-Zugang:https://www.mdpi.com/2218-273X/9/9/475
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