Derepression of the epithelial transcription factor GRHL2 promotes direct hepatocyte-to-cholangiocyte transdifferentiation.

The liver's regenerative capacity is underscored by the plasticity potential of adult hepatocytes. In this context, hepatocyte-to-cholangiocyte transdifferentiation (HCT) has been ascribed with pro-regenerative functions in animal models and is a feature of end-stage human chronic liver diseases. Wh...

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Hlavní autoři:	Ludivine Vasseur, Céline Gheeraert, Julie Dubois-Chevalier, Ninon Very, Loïc Guille, Mohamed Bou Saleh, Clémence Boulet, Cyril Sobolewski, Pascal Loyer, Alexandre Berthier, Noémie Legrand, Anne Corlu, Viviane Gnemmi, Guillaume Lasailly, Emmanuelle Leteurtre, Dmitry Galinousky, Antonino Bongiovanni, Solenne Taront, Nicolaj I Toft, Lars Grøntved, David Tulasne, Alessandro Furlan, Line Carolle Ntandja-Wandji, Bart Staels, Philippe Lefebvre, Laurent Dubuquoy, Jérôme Eeckhoute
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2025-12-01
Edice:	PLoS Biology
On-line přístup:	https://doi.org/10.1371/journal.pbio.3003547
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